In the last years, lipidomics has emerged as a rapidly evolving tool in many fields of science. In our laboratory, we are particularly interested in unravelling the complex role of the wide range of lipids in the pathogenesis of disease (e.g. cancer). To this end, we are deeply committed in the development of workflows and tools focused on improving lipidome analysis and lipid annotation when liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS) approaches are used.
FAMetA
FAMetA is an R-based tool aimed to the analysis of fatty acids (FA) metabolism. It allows the estimation of FA import (I), de novo synthesis (S), fractional contribution of 13C-tracers (D0, D1, D2), elongation (E) and desaturation (Des) based on 13C mass isotopologue distributions.
Input data formats and tutorials can be found at the above links but, in case you have further questions or you find any bug, please send an email to maribel_alcoriza@iislafe.es with the required information (input data and parameters).
License
This program is free software; you can redistribute it and/or modify it under the terms of the GNU General Public License as published by the Free Software Foundation; either version 2 of the License, or (at your option) any later version.
This program is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU General Public License for more details.
References:
1. LipidMS: An R Package for Lipid Annotation in Untargeted Liquid Chromatography-Data Independent Acquisition-Mass Spectrometry Lipidomics. Anal Chem, 2019.
(doi:10.1021/acs.analchem.8b03409)
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